Alpha Lipoic Acid Attenuates Radiation-Induced Thyroid Injury in Rats

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Alpha lipoic acid attenuates radiation-induced oral mucositis in rats

PURPOSE Radiotherapy is currently one of the main treatment modalities for head and neck cancer; however, it also results in severe toxicity to the normal tissue, to the detriment of patients. This study aimed to investigate whether alpha lipoic acid (ALA) could protect against radiation-induced oral mucositis in a rat model. RESULTS On post-irradiation days 4 and 7, the epithelial layer on o...

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Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats

PURPOSE Radiation therapy is a treatment for patients with head and neck (HN) cancer. However, radiation exposure to the HN often induces salivary gland (SG) dysfunction. We investigated the effect of α-lipoic acid (ALA) on radiation-induced SG injury in rats. RESULTS ALA preserved acinoductal integrity and acinar cell secretary function following irradiation. These results are related to the...

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Alpha-Lipoic Acid Attenuates Renal Injury in Rats with Obstructive Nephropathy

This study was established to determine the possible protective effects of alpha-lipoic acid (ALA), a powerful antioxidant, on renal injury in obstructive nephropathy. Male Sprague-Dawley rats were assigned into sham-operated unilateral ureteral obstruction (UUO) and UUO treated with ALA groups. ALA 60 mg/kg was injected intraperitoneally 2 days before UUO induction and continued afterward for ...

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Protective effects of alpha-lipoic Acid on oleic Acid-induced acute lung injury in rats.

BACKGROUND Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). AIMS The aim of this study was to investigate the possible protective role of alpha-lipoic acid (α-LA) on oleic acid (OA)-induced ALI in rats. STUDY DESIGN Animal experiment. METHODS A total of thirty-five rats were divided into five groups in the study. Group 1 served as a co...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0112253